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Artificial cannabinoids surface in several CBD models in products such as gummy bears and vape cartridges.[36]

Some early artificial cannabinoids were being also utilized clinically. Nabilone, a first era artificial THC analog, has long been utilized as an antiemetic to beat vomiting and nausea due to the fact 1981.

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PB-22 and 5F-PB-22 were the first synthetic cannabinoids to incorporate a quinoline substructure and an ester linkage. These compounds are assumed to are actually synthesized While using the intention of creating a artificial cannabinoid prodrug, which could strengthen absorption and confound detection. Ester bonds are effortlessly biodegradable by way of spontaneous or endogenous, nonspecific esterase hydrolysis, that has been frequently used in medicinal chemistry to help make ester prodrugs.

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